O-GlcNAcylation negatively regulates phosphorylation of tau:A novel mechanism involved in Alzheimer's disease
作者单位：Jiangsu Key Laboratory of NeuroregenerationNantong University epartment of NeurochemistryNew York State Institute for Basic Research in Developmental Disabilities1050 Forest Hill RoadStaten IslandNew York 10314U.S.A. Department of NeurochemistryNew York State Institute for Basic Research in Developmental Disabilities1050 Forest Hill RoadStaten IslandNew York 10314U.S.A.
会议名称：《2008年全国糖生物学学术会议》
会议日期：2008年
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
摘 要：Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with Alzheimer’s disease(AD)and other tauopathies. Tau pathology is critical to pathogenesis and correlates to the severity of ***,the