Blocking CCL20 can attenuate the impact of dendritic cells on COPD
作者单位：Department of Respiratory MedicineAffiliated Hospital of Zunyi Medical College
会议名称：《中华医学会呼吸病学年会——2013（第十四次全国呼吸病...》
会议日期：2013年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Objectives To investigate the expressions of dendritic cells(DCs) and its chemokine receptors in this rat model of COPD and the therapeutic effect of anti-CCL20 therapy on it. Methods 18 Wistar rats were randomized into a control group,a COPD model group and a CCL20 monoclonal antibody treated *** the latter two groups,COPD was induced by established cigarette smoke inhalation about four weeks and intratracheal 200ug/200ul of LPS solution twice ***20 monoclonal antibody was