Unification of Anion Relay Chemistry(ARC) with the Takeda and Hiyama/Denmark Cross-Coupling Reactions:Identification of an Effective Silicon-Based Transfer Agent
作者单位：Department of ChemistryPenn Center for Molecular Discovery and the Monell Chemical Senses CenterUniversity of PennsylvaniaPhiladelphiaPA19123
会议名称：《化学使世界更美好——中国化学会第七届有机化学学术会议》
会议日期：2011年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：Anion Relay Chemistry Natural Product Synthesis Diversity-Oriented Synthesis Brook Rearrangement Cross-Coupling
摘 要：Anion Relay Chemistry(ARC),an effective multi-component union protocol,recently developed and employed in our laboratory,holds great potential for chemists requiring rapid increase of molecular complexity in a single operation,with precise control of stereogenicity on route to both natural and natural product-like targets for biomedical research. Employing this technique,a large number of diverse structures can be assembled rapidly from a small number of initiating nucleophiles,bifunctional linchpins,and electrophiles in a controlled,multi-component coupling *** to expand the scope of this tactic include the construction of natural products, as well as libraries of natural product-like compounds, which highlight the robust nature of this *** of the ARC tactic,involving both TypeⅠand TypeⅡprotocols,will be presented with illustrations arising from alkaloid and polyketide/macrolide total synthetic ventures currently ongoing in our *** addition,observations regarding the intersection of the ARC TypeⅡprotocol with previously reported reaction pathways, notably in the area of Pd-mediated Takeda and Hiyama/Denmark cross-coupling reactions,will be presented.