The majority of CD1d-sulfatide-specific T cells in human blood use a semi-invariant Vδ1 TCR
作者单位：Committee on Immunology and Department of Pathology Howard Hughes Medical Institute University of Chicago Institute of Immunology School of Life Sciences University of Science and Technology of China
会议名称：《第八届全国免疫学学术大会》
会议日期：2012年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
摘 要：αβT-cell lines specific for sulfatide,an abundant myelin glycosphingolipid presented by various CD1 molecules,have been previously derived from PBMCs of patients with demyelinating diseases such as multiple sclerosis(MS)but also from healthy *** an unbiased tetramer-based MACS enrichment method to enrich for rare antigen-specific cells,we confirmed the presence of CD1d-sulfatide-specific T cells in all healthy individuals ***,the great majority of fresh sulfatide-specific T cells belonged to theγδ***,these cells used the Vδ1 TCR variable segment,which is uncommon in the blood