Mechanisms of gut homeostasis in Drosophila
作者单位：College of Life SciencesCapital Normal University
会议名称：《第二届全国发育生物学大会》
会议日期：2014年
学科分类：0710[理学-生物学] 07[理学] 09[农学]
关 键 词：Drosophila stem cell tissue homeostasis Dpp Debra.
摘 要：Homeostasis in adult tissues is maintained by resident stem cells and their *** proliferation of adult stem cells and differentiation of their progeny must be tightly *** of the best examples is the adult gastrointestinal epithelium which is constantly being renewed with the progeny of *** of the regulatory mechanisms could result in the depletion of stem cells or in excessive proliferation of stem cells/progenitor cells,eventually leading to diseases such as *** regulatory networks will yield insights into the mechanisms of related human *** and Drosophila intestines show marked similarities in terms of development,cellular make-up and genetic ***,studying the mechanisms in homeostasis control will help the understanding of homeostasis maintenance and tumorogenesis,having potential clinical ***,the mechanisms how it controls ISC proliferation and differentiation are not fully *** found that both extrinsic and intrinsic factors regulate midgut ***-derived Decapentaplegic(Dpp)is essential for adult midgut *** show that Dpp signaling is primarily activated in enterocytes(ECs).Depletion of Dpp signaling in ECs results in excess amounts of intestinal stem cell(ISC)-like cells and their ***,we find that Dpp is expressed specifically in tracheal cells that reach the intestinal cells through the visceral muscles(VMs).Depletion of dpp expression in tracheal cells phenocopies the Dpp loss-of-function defects in *** data demonstrate that the Drosophila trachea not only exchanges air for bodily needs,but also produces a Dpp morphogen essential for neighboring tissue ***,we found that Debra-mediated Ci degradation is important for ISC *** inhibition leads to increased ISC activity and tissue homeostasis loss,phenocopying defects observed in the aging *** defects can be suppressed by deplet