Silver-Catalyzed Intramolecular Cyclization of o-（1-Alkynyl）benzamides:Efficient Synthesis of （1 H）-Isochromen-1-imines

作     者：Guannan Liu,~a Yu Zhou,~a Deju Ye,~a Dengyou Zhang,~a Xiao Ding,~a Hualiang Jiang,~a Hong Liu~(a,*) a Drug Discovery and Design Centre,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Science 555 Zuchongzhi Road,Shanghai 201203,China 

会议名称：《第六届全国化学生物学学术会议》

会议日期：2009年

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：National Natural Science Foundation of China(Grant 20721003 and 20872153) International Collaboration Projects(Grant 2007DFB30370 and 20720102040) 863 Hi-Tech Program of China(Grants 2006AA020602 and 2006AA 10A201) 

摘      要：正Isocoumarins are key core structural subunits that occur in a wide variety of biologically active natural products and synthetic complex molecules,as well as useful versatile synthetic intermediates. Recently,the activity of isocoumarins as potent anticancer agents invoked additional interest in the investigation of them and their *** there is a remarkable similarity in reactivity and