Olefination of Benzylzinc Halide with Aryl Acetone

作     者：WANG, Ke-Hu LI, Hong-Xia MEN, Xiu-Qin WANG, Jin-Xian (Institute of Chemistry, Department of Chemistry, Northwest Normal University, Lanzhou 730070) 

会议名称：《中国化学会第四届有机化学学术会议》

会议日期：2005年

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Project supported by the National Natural Science Foundation of China (No. 20272047) the Gansu Key Laboratory of Polymer Materials and the Northwest Normal University Science and Technology Development Foundation of China 

摘      要：正Alkene formation reactions are important tools in organic synthesis and a variety of methodologies have been devised for the conversion of carbonyl compounds into alkenes. Since Professor Georg Wittig discovered in 1953 the reaction of phosphonium ylides with carbonyl compounds to form alkenes, a variety of reagents have been developed for this transformation by a number of chemists. We have reported that organozinc halide reacts with aryl aldehydes in the presence of a silylating agent and using [NiCl2（PPh3）2] as the catalyst obtaining E-stilbenes. Herein, we report the reaction of benzylzinc halide with aryl acetones using Pd（PPh3）2Cl2 as the catalyst and obtained a series of E-stilbenes in good to excellent yields under mild conditions.