New insights into the functions and signaling pathways of myostatin in regulating cell proliferation and metabolisms
作者单位：National Laboratory of Medical Molecular BiologyDepartment of Biochemistry and Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术...》
会议日期：2010年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
摘 要：Myostatin,also named GDF-8(Growth and Differentiation Factor-8),is a member of the TGF-fi superfamily and has been emerged as a important regulator of skeletal muscle *** gene is highly conserved in mammalian *** in cattle,sheep,dogs,and one child cause an dramatic increase in skeletal muscle mass,suggesting that myostatin normally acts as a negative regulator of muscle *** work from my laboratory has demonstrated that Myostatin could inhibits myoblast cell proliferation through Erkl/2 and PI3K/Akt/GSK3b ***