Efficiency of teniposide plus cisplatin regimen to malignant glioma patients
会议名称：《中国抗癌协会神经肿瘤专业委员会第八届学术会议》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：teniposide cisplatin malignant gliomas
摘 要：Objective:To analyze the efficacy and side-effect of teniposide plus cisplatin regimen on malignant glioma ***:A total of 56 patients with histologically confirmed malignant gliomas（WHO grade III/IV） were *** patients were received radiotherapy following *** were 24 patients received adjuvant chemotherapy and the other 32 patients received salvage *** chemotherapy regimen comprised of VM-26 300mg/m2 plus DDP 80 mg/m2,which were divided for 3-5 days intravenous administration,every 3-4 weeks as a *** clinical efficacy and survival time of the patients were evaluated if the patients who were completed more than two cycles ***:Forty-nine patients were included for evaluation:complete remission（CR） was achieved in 2 cases（4.1%）and 6 cases（12.2%） were partial remission（PR）,while stable disease（SD）were found in 30 patients（61.3%）,and progressive disease（PD） were in 11 cases（22.4%）.Objective response rate（CR+PR） was 16.3%,and disease control rate（CR+PR+SD） was 77.6%.The progression-free survival（PFS） rate at 6 months was 55.1%.The survival rate at 1 year,2 years and 3 years was 63.3%,34.7%,and 20.4%,*** median overall survival time（OS） was 20.8 *** side-effect of the regimen was mainly hematological,with grade 3 or 4 neutropenia in twelve patients（24.5%）,and which was recovered in several days after receiving G-CSF ***:VM-26 plus DDP chemotherapy regimen can achieve fairly high response rate and disease control rate for patients with malignant gliomas,and the toxicity is acceptable.