NRAGE,Neurotrophin receptor interacting MAGE homolog, can bind p53 and and inhibits cell growth

作     者：Chuan-.Jun Wen, Bin Xue, Wen-Xin Qin, Min-Yue Zhang, Dong-Hong Zhao, Xiang Gao, Jiang-Ren Gu, Chao-Jun Li The Key Lab for Molecular Medical Biology, Nanjing Normal University, Nanjing 210097, China Shanghai Institute of Cancer, Shanghai 200032, China Nanjing University Model Animal Research Center, Nanjing University, Nanjing 210097, China 

会议名称：《中国细胞生物学学会第八届会员代表大会暨学术大会》

会议日期：2003年

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

摘      要：A MAGE homologue is cloned through functional screening from human placenta cDNAlibrary. This gene is idenified through sequence comparison to be the human homologue ofrat neurotrophin receptor p75 (p75NTR) interacting MAGE homologue (NRAGE), which caninduce PC12 cell apoptosis upon NGF treatment. We find that hNRAGE can also regulate cellproliferation. Overexpression of hNRAGE can inhibit the colony formation of HEK293,U2OS and HepG2 cell. Cell cycle analysis shows that hNRAGE overexpression blocks cells