The molecular mechanisms of dysfunctional HERG potassium channels caused by A422T mutation

作     者：Jia Guo~1 Xiangmei Zhang~1 Zhengsheng Hu~1 Zhonghua Zhu~1 Zhong Chen~1 Xiaoli Sun~1 Zhonghzong Zhao~(1 2) Zhao Zhang~(1 2) 1 Jiangsu Key Laboratory for Molecular and Medical Biotechnology 2 Jiansu Key Laboratory for Supermolecular Medicinal Materials & Applications College of Life Science Nanjing Normal University Nanjing 210046 China 

会议名称：《The 2nd International and 11th National Symposium on Membrane Biology》

会议日期：2010年

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by NSFC(No.30570662,No.30871228) partly by State Key Development Program of Basic Research of China(2006CB943500) 

摘      要：正Human hereditary long QT syndrome is a cardiac arrhythmic disease characterized by prolongation of the QT interval and increased susceptibility to ventricular arrhythmias and sudden cardiac *** in the human-ether-a-go-go-related gene（hERG） encoding the protein of delayed rectifier potassium channel that mediates cardiac repolarizing current IKr,causes chromosome7-1inked long QT syndrome 2（LQTS2）.Here,we describe that a