New therapeutic approach for Alzheimer disease
作者单位：北京大学医学部神经科学研究所 RIKEN Brain Science Institute JapanTokyo
会议名称：《中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会》
会议日期：2005年
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
关 键 词：amyloid-beta protein aggregate hydrophilic hydroph
摘 要：正The amyloid β-protein （Aβ） 42 plays a pivotal role in Alzheimer disease （AD）. We have previously reported that intracellular Aβ42 is associated with neuronal apoptosis （Chui et al, 1999, Chui et al, 2001）. AD may be caused by toxic aggregates formed from Aβpeptides. By using Thioflavin T, a dye that specifically binds to β-sheet structures, we found that highly toxic forms of Aβaggregates were formed at