The molecular mechanism of substance P into regulated secretory pathway in primary sensory neuron
会议名称：《中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会》
会议日期：2005年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：substance P sorting signal aggregation
摘 要：正Preprotachykinin （PPT） represents one widely distributed neuropeptide family, including substance P （SP） and substance K （SK）. which has various effects such as neural excitation, vasodilatation, secretion and smooth muscles contraction. Mammalian tachykinins are derived from two preprotachykinin genes: the PPT-A gene, which encodes the sequences of SP, SK, and neuropeptide K and neuropeptide-γ, and the PPT-B gene, which encodes the: sequence of NKB. The precursor RNA from PPT-A is alternatively