Synthesis of novel antimicrobial tetrazole compounds and their Supramolecular synergistic effects with clinical drugs
作者单位：School of Chemistry and Chemical Engineering Southwest University 中央研究院(台湾)科学院生物化学研究所
会议名称：《全国第十七届大环化学暨第九届超分子化学学术研讨会》
会议日期：2014年
学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学]
基 金：partially supported by National Natural Science Foundation of China(21172181,21372186) the Research Fund for International Young Scientists from International(Regional)Cooperation and Exchange Program NSFC(No.81450110095)
关 键 词：Tetrazole Amine Antifungal
摘 要：正A series of tetrazole type of antifungal compounds were synthesized and characterized by NMR,IR,MS and HRMS *** bioactive assay manifested that most target compounds exhibited good antifungal activity,especially compound 7g with 2-chlorobenzyl derivative displayed comparable or even stronger antifungal