DNA polymerase iota is regulated by DNA damage checkpoint controlled JNK/c-Jun signaling and associated with hypermutagenesis in bladder cancer
作者单位：Department of Cell BiologyThe Third Military Medical University
会议名称：《细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉》
会议日期：2013年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：bladder cancer/DNA polymerase iota/JNK signaling/mutagenesis/UV damage
摘 要：Human DNA polymerase iota(pol(?)) possesses error-prone DNA replication features and performs translesion DNA *** may be specialized and highly regulated in normal mammalian cells;dysregulation of pol(?) may contribute to the acquisition of a mutator ***,there are few reports describing the transcriptional regulatory mechanisms of pol(?),and there is controversy