Lipoprotein lipase deficiency leads to α-synuclein accumulation through down regulating UCHL1 gene expression
作者单位：Neuroscience Research InstitutePeking University Dep.of Neurology Third HospitalPeking University Institute of Cardiovascular SciencesPeking University
会议名称：《第11届全国脂质与脂蛋白学术会议》
会议日期：2012年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：supported by the National Natural Science Foundation of China (NSFC Grants No.30973145,81171015) Doctoral Fund of Ministry of Education (20090001110058) 973 Program(No.2012CB911000,No.2012CB911004)
摘 要：LPL is a key enzyme hydrolyzing plasma triglyceride carried in very low density lipoproteins(VLDLs) and chylomicrons(CMs).The major sites of expression of LPL are in adipose tissue and skeletal *** studies revealed the presence of LPL mRNA and activity in the brain in several mammalian species, including rat,mouse,and *** is involved in the pathogenesis of dementia. Our lab also found that LPL-deficient mice display impaired ***