Asymmetric Synthesis ofβ-CF3-β-Amino Acid via Aza-Morita-Baylis-Hillman Reaction Betweenα,β-Unsaturated Esters and 2-Methyl-N-（2,2,2-Trifluoroethylidene）Propane-2-Sulfinamide
作者单位：College of Chemistry Chemical Engineering and Biotechnology Donghua University 2999 North Renmin Road Shangghai 201620 China
会议名称：《中国化学会第十二届全国氟化学会议》
会议日期：2012年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
摘 要：正Synthetic studies on fluorinatedα- andβ-amino acids as biologically relevant buiding blocks for synthesis of peptides andβ-lactams have attracted considerable attention in the past decades. 2-Methyl-N-（2,2,2-trifluoroethylidene）propane- 2-sulfinamide（1）,firstly reported by Kuduk in 2006 ,which was rapidly becoming a noticeable intermediate for the asymmetric synthesis of fluorinated