Non-myeloablative conditioning is sufficient to induce mixed chimerism and subsequent acceptance of donor specific cardiac and skin grafts
作者单位：Guangdong Cardiovascular InstituteGuangdong General
会议名称：《2013中国器官移植大会》
会议日期：2013年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
摘 要：Objective Organ transplant recipients have elevated cancer and viral infection risks due to immunosuppression and long—term results of organ transplantation remain unsatisfactory,mainly because of chronic *** purpose of the current study is to establish a nonmyeloablative perioperative regimen,able to induce mixed chimerism and tolerance of allografts. Method To establish a nonmyeloablative perioperative regimen,we used Busulfan,an important component of many bone marrow transplantation preparative regimens for a variety of non-neoplastic diseases as an alternative to total body irradiation(TBI),and FTY720,a unique immunosuppression agent,inhibition lymphocyte *** found that creating a lymphohematopoietic chimera in which donor and recipient hematopoiesis coexist resulted in prolongation of the donor specific heart and skin allografts.