Amip inhibits mesoderm induction activity of Nodal in zebrafish
会议名称:《中国细胞生物学学会第八届会员代表大会暨学术大会》
会议日期:2003年
学科分类:0710[理学-生物学] 07[理学] 071003[理学-生理学]
摘 要:Nodal is a TGFβ-related factor and has been identified as a key endogenous inducerfor both mesoderm and endoderm during vertebrate embryogenesis. In zebrafish,concurrent deficiency of Sqt and Cyc, two Nodal-related factors, lead to absence ofmost mesodermal and endodermal tissues in embryos. Here we report a zebrafishgene amip that encodes a novel component of the Nodal signaling pathway inzebrafish. amip mainly expresses in the territories where Sqt and Cyc have inductiveactivities during midblastula and gastrulation period. The expression of amip isnegatively autoregulated but activated by Nodal signaling. Knocking-down of Amip