Abnormal Social Behavior in Mice Co-exposed to BPA and Pb
会议名称：《中国畜牧兽医学会家畜内科学分会第七届代表大会暨学术研讨...》
会议日期：2011年
关 键 词：social behavior BPA Pb sex-specific
摘 要：Alerted sociability is the core feature of a variety of human neurological disorders such as autism. Autism is a neurodevelopmental disorder characterized by impaired communication,repetitive behaviors and aberrant reciprocal social interactions.While the etiology remains unclear,strong evidence exists for environmental risk factors,and environmental toxins have been implicated.Bisphenol A(BPA) and Lead(Pb), informed neurotoxciants.are widely used in industry and daily life.BPA and Pb combined exposure models have been established in this study.To understand the relationship between combined exposure of BPA and Pb and the diagnostic and associated symptoms of autism,behavioral phenotyping of mouse exposed to BPA and Pb was conducted by investigating general health factors including physical abilities,social interactions.Results from our behavioral phenotyping battery indiaed that treated mouse were similar to the control on standardized measures of general health.Remarkably,sex-specific sociability decreased in male mice co-exposed to BPA and Pb.Our finding supported the interpretation that BPA and Pb combined exposure could be the risk factor for autism.