Precise spatiotemporal patterns of neuronal network activation during persistent reverberatory activity
作者单位：Hefei National Laboratory for Physical Sciences at the Microscale and School of Life ScienceUniversity of Science and Technology of China
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：neural network cell assembly multielectrode array reverberation
摘 要：正In Hebb’s theory of the cell assembly,short-term memory traces can be stored in closed loop neuronal circuits in form of persistent reverberatory *** previous studies,we have observed persistent network reverberation in cultured hippocampal neurons（Lau and Bi,PNAS,2005）.Here,we investigated the spatiotemporal dynamics of such collective activity of neurons grown on multi-electrode arrays（MEAs）.In this preparation,a reverberation episode consisted of many distinct population bursts defined as reverberation event,each involved the spiking activity of many neurons within a time span of tens of ***,we developed a robust method to define the similarity between two events and use it to find conserved patterns among all *** found that there existed conserved spatiotemporal patterns with high temporal precision in cultured neuronal ***, multiple patterns could co-exist in the same network during spontaneous reverberation and could occur intermittently within the same reverberation *** smaller networks,reverberation could only be evoked by stimulating an input channel,and sometimes only one conserved pattern was *** results suggested that precise spatiotemporal dynamics in neural circuits might allow for more efficient information coding in the brain.