The association between atrial amyloidosis and atrial fibrillation
会议名称：《中华医学会心电生理和起搏分会第十次全国学术年会》
会议日期：2012年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Objective Structural changes,like atrial fibrosis,may increase the likelihood of atrial fibrillation (AF) occurring in response to triggering *** influence of atrial amyloidosis is largely unknown. Methods Right atrial appendages(1 or 2 entire cross sections) were obtained from 27 patients undergoing open-heart *** amyloid was identified by Congo red staining and classified by *** was found every patient,significant amyloidosis(the Amyloidosis area accounted for more than 50%of the total area)was found in 20(74.1%) of 27 patients,and all deposits were immunoreactive for transthyretin(TTR) and trial natriuretic peptide(ANP),of which TTR is more significant. Results Fourteen(51.9%) patients suffered from persistent *** presence of amyloid correlated with age and P-wave duration and was related to sex,valve diseases,and the presence of AF(P=0.043). The association between atrial amyloid,AF,and P wave duration was independent of age and sex. According to multiple logistic regression analysis,amyloid was the only age- and sex-independent predictor for the presence of *** fibrosis was not a predictor for AF,but the amount of atrial fibrosis was related with atrial fibrillation. Conclusions Our study provides evidence that atrial amyloidosis affects atrial conduction and increases the risk of *** occurrence of atrial amyloidosis depends on age leading to the formation of an amyloid *** progression and consequences of atrial amyloidosis are then influenced by pathological conditions,such as valve *** correlation between atrial amyloidosis and atrial fibrillation suggests that these patients may not benefit from treatment with ACE inhibitors to reduce the amount of atrial fibrosis.