FKBP12.6 plays a vital role in regulating hippocampal neuron signaling in mice

作     者：Shaopeng Chi,Qi Yuan,Yanyun Wu,Guangiu Ji National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,15 Datun Road,Chaoyang District,Beijing 100101,China. 

会议名称：《第十七届国际生物物理大会;第十二届中国生物物理大会》

会议日期：2011年

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

关 键 词：FKBP12.6 memory and motility behaviors hippocampal neurons apoptosis 

摘      要：As has been known that hippocamp plays a major role in learning and *** studies indicate that intracellular calcium release channel ryanodine receptor isoform 2(RyR2) is richly expressed in CA3 and Dentate gyrus areas in hippocamp and plays an important role in memory and spatial learning *** like ***12 which associates with RYRl,protein FKBP12.6 more selectively associates with RYR2 which