Design and Synthesis of Novel Amido Tetra-Nitroimidazole as Potential Anticancer Agent

作     者：Cao,Shouying Zhou,Chenghe~* (School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715) 

会议名称：《有机合成创新—产业化的新动力——中国化学会全国第三届有机合成化学与过程学术讨论会》

会议日期：2010年

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基　　金：supported by Natural Science Foundation of Chongqing(CSCT:2007BB5369) Southwest University(SWUB2006018,XSGX0602) 

关 键 词：nitroimidazole synthesis anticancer 

摘      要：The new millennium has witnessed considerable decrease in a number of previously fatal pathologies,largely due to the advancement in molecular medicine and modern approaches to *** spite of this success, neoplastic disease(cancer) remains a serious problem due to several reasons.A novel group of clinically interesting anticancer drugs has been a recent focus holding substantial promise as selective anticancer drugs. Imidazole compounds have been shown to suppress several types of cancer in animal models,including breast,