Replication priority of hepatitis C virus genotype 2a in a Chinese cohort
会议名称：《2012年中国药学大会暨第十二届中国药师周》
会议日期：2012年
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：supported by the"Key Program for the Control of Infectious Diseases" the 973 program of the Ministry of Science and Technology,PR China(JDJ)
关 键 词：HCV genotype viral load antibody response
摘 要：Background and Aim: HCV genotypes have been documented in clinical *** goal of this study is to learn viral replication capacity of different HCV genotypes in human ***: 491 otherwise healthy Chinese blood donors with positive HCV antibody reaction were employed in the *** subjects were not being treated with antiviral drugs *** genotyping was determined followed by serum viral load *** antibody reaction against HCV Core,NS3,NS4 and NS5 epitope antigens was analyzed,respectively,for each of the ***: Genotyping analysis showed that among these individuals 6.7% was infected with genotype 1a,41.5% with 1b,36.0% with 2a,6.7% with 2b,2.6% with 3a,1.8% with 3b,2.4% with 6 and 2.0% *** 1b and 2a were the predominant ones in this Chinese cohort,causing 77.6% HCV *** the genotype groups,individuals infected with genotype 2a had a HCV RNA viral load （108copies/ml） over 100-fold （2.3log） higher than that infected with other genotypes （104-105copies/ml）,indicating a replication priority of genotype *** is no correlation between HCV genotype and antibody response against HCV Core,NS3,NS4 and NS5 epitope *** appears that the amplification advantage of genotype 2a results from its nature of favorable interaction with host cellular ***: HCV genotype 1b and 2a are both the predominant genotypes in China;of the seven HCV subtypes analyzed genotype 2a possesses a significant replication priority in this Chinese cohort.