Design,Synthesis,and Biological Evaluation of Imidazoline Derivatives as p53-MDM2 Binding Inhibitors
会议名称:《2011年全国药物化学学术会议——药物的源头创新》
会议日期:2011年
学科分类:1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学]
基 金:Supported by NSFC(30873163) Zhejiang Innovation Program for Graduates(YK2010012) the Scholarship Award for Excellent Doctoral Student granted by Ministry of Education
关 键 词:p53-MDM2 binding inhibitor Nutlin anti-cancer
摘 要:正The tumor suppressor p53 is a powerful antitumoral molecule frequently inactivated by mutations or deletions in *** recent years,the activation by antagonizing the negative regulator of p53-MDM2(murine double minute 2,or HDM2 for the human congener) offers a new therapeutic *** series of 25 novel imidazoline derivatives were designed,synthesized