Design,Synthesis,and Biological Evaluation of Imidazoline Derivatives as p53-MDM2 Binding Inhibitors

作     者：Chunqi Hu,Yongzhou Hu~* ZJU-ENS Joint Laboratory of Medicinal Chemistry,Zhejiang University,Zijingang Campus,Hangzhou 310058,China 

会议名称：《2011年全国药物化学学术会议——药物的源头创新》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：Supported by NSFC(30873163) Zhejiang Innovation Program for Graduates(YK2010012) the Scholarship Award for Excellent Doctoral Student granted by Ministry of Education 

关 键 词：p53-MDM2 binding inhibitor Nutlin anti-cancer 

摘      要：正The tumor suppressor p53 is a powerful antitumoral molecule frequently inactivated by mutations or deletions in *** recent years,the activation by antagonizing the negative regulator of p53-MDM2（murine double minute 2,or HDM2 for the human congener） offers a new therapeutic *** series of 25 novel imidazoline derivatives were designed,synthesized