Clinical Analysis of Non-Hodgkin's Lymphoma Presenting in Oral & Maxillofacial Region

作     者：Subhash Kumar Ghimire 

作者单位：大连医科大学 

学位级别：硕士

导师姓名：王如

授予年度：2007年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主      题：non-Hodgkin’s lymphoma oral &maxillofacial neoplasms immunohistochemistry Ann Arbor staging system constitutional B symptom Ann Arbor system working formulation Waldeyer’s ring 

摘      要：Objective: Non-hodgkin’s lymphoma (NHL) refers to a group of malignant neoplasms that arise from cellular elements of lymphoid or extranodal tissue. Lymphomas are a frequent cause of malignant lymphadenopathy in the head &neck. The head &neck is the second must frequent anatomical site of extranodal lymphomas after gastrointestinal tract. That’s why dental & maxillofacial surgeon should be aware of malignant lymphoma to diagnose properly & efficiently. This study was performed to evaluate oral & maxillofacial region manifestations, staging, grading and prognosis of NHL. Materials & Method: A retrospective analysis or review of 25patients with oral &maxillofacial region lymphoma was made in our hospital (Dalian Medical University, Stomatology Department of First Affiliated hospital) from 2002jan to 2006 august .Specifically, clinical presentation, staging, grading & therapy for NHL with oral &maxillofacial region involvement were sought. Staging was done according to the Ann Arbor staging system and diagnosis made by immunohistochemistry. Result: 25 patients of NHL were included in our study, among them 20(80%) patients with extra nodal (eNHL) &5(20%) patients with nodal (NHL) involvement. The incidence rate increases exponentially with age between 24 and 79 years. The median age at the diagnosis of the patients was *** above 50 years were 72%.Male (60%) is slightly more than female (40%). Among 20 patients, NHL of Waldeyer’s ring was the most frequent site occurring in 10 patients (50%) followed by NHL of oral cavity (20%), of salivary glands (30%). Constitutional B symptomatology was uncommon, occurring in 25% patients. The typical clinical appearance is a painless local mass lateral or bilateral (90%) and confused with squamous cell carcinoma. Most of the non-Hodgkin’s lymphoma was B-cell lineage (90%), & overall diffuse large B-cell lymphoma (76%) was the most common type. Mostly patients involving non-Hodgkin’s lymphoma in oral &