Synthesis of2-Oxazolines Using DAST via Beckmann Rearrangement
作者单位：东北师范大学
学位级别：硕士
导师姓名：Xihe Bi
授予年度：2013年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
摘 要：In the recent few decades, discovery of the DAST mediated reaction system for organic reactions to form oxazolines has effected drastic and far-reaching changes in the scientific domain. This invention has engrossed the interest of chemists and is increasing our understanding of how a range of organic synthetic processes are enhanced.-its alluring tendency has been marked by numerous applications such as gasoline （petrol and diesel） and lube oil additives, pharmaceutical industries, surface-active agent, corrosion resistant coating, anti-foaming agents, textile chemicals, adhesives and binders, stabilizers for chlorinated hydrocarbons;thus justifying the rigorous research on the oxazoline compound. Today, extraordinary transformations to various natural products and biologically active molecules have been achieved where various oxazolines are useful as intermediates. Oxazoline intermediates entertain a great diversity of reaction patterns that can stand numerous functional groups. Additionally, oxazoline synthetic protocols using DAST are economically captivating procedures as most procedures have been used as surrogate for the traditionally tedious, toxic and sometimes unreliably low product-yielding. In recent progresses, demonstrations from various researchers make free from ambiguity the contributions of the versatility of modern oxazoline synthesis in the development of pharmaceutical libraries, and also in the polymer, material and petroleum industries. In our special case, methodologies used with other systems are mentioned in passing as a justification as to why oxazolines are considered to be species with special powers. Encouraged by the virtues of this, we have conveniently developed a method for the synthesis of highly functionalized2-oxazolines in a one pot component reaction of Ketoximes using DAST via Beckmann rearrangement. Our choice for using DAST was intended for the development of simple, safe and efficient method for their synthesis of
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