A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

作     者：Shuai Guo Bei Liu Mengjie Zhang Chunhui Li Xiaoxia Wang Yuhua Weng Lele Li Yuanyu Huang Shuai Guo;Bei Liu;Mengjie Zhang;Chunhui Li;Xiaoxia Wang;Yuhua Weng;Lele Li;Yuanyu Huang

作者机构：School of Life ScienceAdvanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyInstitute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China School of PharmacyHunan University of Chinese MedicineChangsha 410208China College of Materials Science and Optoelectronic TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China Hunan University of Science and EngineeringYongzhou 425199China Institute of Molecular MedicinePeking UniversityBeijing 100871China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第1期

页      面：102-106页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100215[医学-康复医学与理疗学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the Hunan Provincial Natural Science Foundation of China(Nos.2018JJ1019,2019JJ50196) the Hu-Xiang Young Talent Program(No.2018RS3094) the National Natural Science Foundation of China(Nos.31871003,31901053) the Beijing Institute of Technology Research Fund Program for Young Scholars and the Fundamental Research Funds for the Central Universities(No.2018CX01023) the Beijing-Tianjin-Hebei Basic Research Cooperation Project(No.19JCZDJC64100) the Beijing Nova Program from Beijing Municipal Science&Technology Commission(No.Z201100006820005) the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology(2020-2022) 

主　　题：FeOOH siRNA delivery RRM2 RNA interference Polyetherimide Cancer treatment 

摘      要：Despite the promising prospect of small interfering RNA(siRNA) for the treatment of diverse diseases,it remains challenging to develop novel delive ry materials to desired tissues and *** this study,a novel iron oxyhydroxide(FeOOH) nanoparticle(NP) whose surface was modified with branched polyetherimide(PEI) was developed to deliver siRNA into the cancer *** was demonstrated that PEI-FeOOH(PFeOOH) efficiently complexed siRNA,mediated effective cellular uptake and endosomal escape,thereby triggering robust gene silencing in *** addition,PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues,and exhibited excellent safety profiles in ***,this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.