Emerging data supporting stromal cell therapeutic potential in cancer:reprogramming stromal cells of the tumor microenvironment for anti-cancer effects

作     者：Armel H.Nwabo Kamdje Paul F.Seke Etet Richard Tagne Simo Lorella Vecchio Kiven Erique Lukong Mauro Krampera Armel H. Nwabo Kamdje;Paul F. Seke Etet;Richard Tagne Simo;Lorella Vecchio;Kiven Erique Lukong;Mauro Krampera

作者机构：Department of Biomedical SciencesUniversity of NgaoundereFaculty of ScienceNgaoundere 454Cameroon Department of Physiological Sciences and BiochemistryUniversity of NgaoundereGaroua 454Cameroon Center for Sustai nable Health and DevelopmentGaroua 454Cameroon Department of BiochemistryMicrobiology&ImmunologyUniversity of SaskatchewanCollege of MedicineSaskatoon SK S7N 5E5Canada Department of MedicineUniversity of VeronaSection of HematologyStem Cell Research LaboratoryVerona 37134Italy 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2020年第17卷第4期

页      面：828-841页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Stromal cells tumorigenic effects anti-cancer effects tumor microenvironment reprogramming 

摘      要：After more than a decade of controversy on the role of stromal cells in the tumor microenvironment,the emerging data shed light on pro-tumorigenic and potential anti-cancer factors,as well as on the roots of the *** discuss the pro-tumorigenic effects of stromal cells,considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells,as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment,and cancer initiating cells cellular senescence and adaptive *** summarize the emerging data supporting stromal cell therapeutic potential in cancer,discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects,and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature.