Maternal periconceptional consumption of pickled vegetables and risk of neural tube defects in offspring

作     者：LI Zhi-wen ZHANG Let YE Rong-wei LIU Jian-meng PEI Li-jun ZHENG Xiao-ying REN Ai-guo 

作者机构：Institute of Reproductive and Child Health/Ministry of Health KeyLaboratory of Reproductive Health Peking University HealthScience Center Beijing 100191 China Institute of Population Research/WHO Collaborating Center onReproductive Health and Population Science Peking UniversityBeijing 100871 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第11期

页      面：1629-1633页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This study was supported by the grants from the National Key Technologies Research and Development Program (No.2002BA709B11) and the State Key Development Program for Basic Research China (No.2007CB5119001) 

主　　题：birth defects case-control study neural tube defects pickled vegetables 

摘      要：Background Maternal exposure to nitrate, nitrite, and N-nitroso compounds from drinking water or diet has been associated with an increased risk of neural tube defects （NTDs） in some studies. Pickled vegetables contain relatively large amounts of nitrite and N-nitroso compounds. We examined the association between maternal periconceptional consumption of pickled vegetables and NTDs in Shanxi Province of northern China. Methods Data were derived from a population based case-control study of major external birth defects in four counties of $hanxi Province. Participants included 519 NTDs cases identified between 2003 and 2007 and 694 healthy controls. Exposure information was collected within 1 week after delivery. Multivariable non-conditioanal Logistic regression model was used to estimate the adjusted odds ratio （OR） controlling for potential confounding variables.