Mechanical stimulation of the scalp improves the extra-and intracranial blood circulation in humans and mice

作     者：Yan Tan Fang He Ce Zhang Jiani Zhang Ziwei Chen Xu Wang Peng Wei Yinan Nan Louis Lei Jin Qian Hua Yan Tan;Fang He;Ce Zhang;Jiani Zhang;Ziwei Chen;Xu Wang;Peng Wei;Yinan Nan;Louis Lei Jin;Qian Hua

作者机构：School of Life SciencesBeijing University of Chinese MedicineBeijing102488China School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing102488China International DepartmentChina-Japan Friendship HospitalBeijing100029China International Institute of Systems MedicineInc.MilwaukeeWI53222USA 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2020年第7卷第4期

页      面：366-374页

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 10[医学] 

基　　金：The work was supported by the National Natural Science Foundation of China(81904049 and 81973690) Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(CACM-2018-QNRC2-C06) 

主　　题：Scalp mechanical stimulation Bloodebrain barrier Capillary Traditional Chinese medicine 

摘      要：Background:Scalp combing,as an ancient method of health care,has been used for thousands of years in traditional Chinese *** this method is considered to be beneficial for the blood circulation of the head,the underlying mechanisms remain ***:Both human participants and mice were used in this *** participants,the scalp was stimulated by combing continuously for 5 min,and the temperature was measured using infrared thermal imaging before and after *** mice,the temperature was determined before and at 5,15,and 30 min after a 5-min scalp mechanical stimulation(SMS).Additionally,the vasculature of the mice was labeled with retro-orbital fluorescein isothiocyanate-dextran injection,and the capillaries were observed directly under a confocal *** in vivo CLARITY imaging and the spectrofluorometric detection of Evans Blue dye extravasation,the bloodebrain barrier permeability was ***:SMS increased the temperature of the left ear significantly in human(P=.0247)while can slightly increase the temperature of the right ear and the face without significant difference(P.05).Moreover,SMS can significantly slow the decrease in the temperature of the external auditory canal at 5 min(P=.0153)and in body temperature at 15 min(P=.0295)after SMS whereas no significant difference in body temperature at 30 min(P.05)compared with control ***,capillaries of the ear with a diameter of less than 8 mm were significantly dilated(P=.0006)following SMS and the number of dextran dots was higher at 15 min(P.05)and 30 min(F=10.98,P=.037)after SMS intervention compared with control ***:Our study provides strong evidence to support the notion that scalp combing can improve extra-and intracranial blood circulation under healthy conditions.