Nanoparticle‑Loaded Polarized‑Macrophages for Enhanced Tumor Targeting and Cell‑Chemotherapy

作     者：Teng Hou Tianqi Wang Weiwei Mu Rui Yang Shuang Liang Zipeng Zhang Shunli Fu Tong Gao Yongjun Liu Na Zhang Teng Hou;Tianqi Wang;Weiwei Mu;Rui Yang;Shuang Liang;Zipeng Zhang;Shunli Fu;Tong Gao;Yongjun Liu;Na Zhang

作者机构：Department of PharmaceuticsKey Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong University44 Wenhuaxi RoadJinan 250012People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2021年第13卷第1期

页      面：79-98页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(81773652 81974498) 

主　　题：Polarized-macrophages Cell therapy Cell-mediated drug delivery Chemotherapy Lipid nanoparticles 

摘      要：Cell therapy is a promising strategy for cancer ***,its therapeutic efficiency remains limited due to the complex and immunosuppressive nature of tumor *** this study,the“cell-chemotherapystrategy was presented to enhance antitumor efficacy.M1-type macrophages,which are therapeutic immune cells with both of immunotherapeutic ability and targeting ability,carried sorafenib(SF)-loaded lipid nanoparticles(M1/SLNPs)were developed.M1-type macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver SF to tumor tissues for chemotherapy simultaneously.M1-type macrophages were obtained by polarizing macrophages using lipopolysaccharide,and M1/SLNPs were obtained by incubating M1-type macrophages with *** accumulation of M1/SLNP was increased compared with SLNP(p0.01),which proved M1/SLNP could enhance tumor targeting of *** increased ratio of M1-type macrophages to M2-type macrophages,and the CD3^+CD4^+T cells and CD3^+CD8^+T cell quantities in tumor tissues after treatment with M1/SLNP indicated M1/SLNP could relieve the immunosuppressive tumor *** tumor volumes in the M1/SLNP group were significantly smaller than those in the SLNP group(p0.01),indicating M1/SLNP exhibited enhanced antitumor ***,M1/SLNP showed great potential as a novel cellchemotherapeutic strategy combining both cell therapy and targeting chemotherapy.