Drug-induced hierarchical self-assembly of poly(amino acid)for efficient intracellular drug delivery

作     者：Zifen Li Yanxue Yang Chuan Peng Hang Liu Rui Yang Yi Zheng Lulu Cai Hong Tan Qiang Fu Mingming Ding Zifen Li;Yanxue Yang;Chuan Peng;Hang Liu;Rui Yang;Yi Zheng;Lulu Cai;Hong Tan;Qiang Fu;Mingming Ding

作者机构：College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Personalized Drug Therapy Key Laboratory of Sichuan ProvinceDepartment of PharmacySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第4期

页      面：1563-1566页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.51873118,21474064,52022062) the KeyResearch and Development Program of Science and Technology Department of Sichuan Province(No.2019YFS0514) Science and Technology Project of Chengdu(No.2019-YF05-00784-SN) the Project of State Key Laboratory of Polymer Materials Engineering(No.sklpme2020-2-03) the Fundamental Research Funds for Central Universities 

主　　题：Poly(amino acid)s Electrostatic complexation Gambogic acid Hierarchical self-assembly Secondary conformation 

摘      要：As a potent anticancer drug,gambogic acid(GA)suffers from its poor water solubility and low chemical stability and shows a limited clinical *** address this problem,we report here a simple and effective strategy to immobilize and deliver GA using a reducible diblock poly(amino acid)as a *** electrostatic interaction between GA and polymer enables a high drug loading content up to 53.6%.Moreover,the drug complexation induces a micelle-to-vesicle transformation,combined with a conformation tra nsition from random coil to *** hierarchically assembled drug nanocomplexes can serve as a smart carrier for efficient cell internalization and triggered release of multiple drugs under intracellular acidic and reductive conditions,resulting in a synergistic antitumor efficacy in *** work provides a new insight into the drug-carrier interaction and a facile nanoplatform for drug delivery applications.