乳房切除术后淋巴水肿部位发生Sweet综合征

作     者：Garca-Ro I. Pérez-Gala S. Aragüés M. 周少娜 

作者机构：Dermatology Department Hospital de La Princesa Diego de León 62 28006 Madrid Spain 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第6期

页      面：11-11页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：Sweet综合征 淋巴水肿 切除术后 腋窝淋巴结清扫术 皮质激素治疗 抗生素治疗 自身免疫性疾病 女性患者 乳房 组织病理特征 

摘      要：Background: Sweet’s syndrome (SS) has been reported in association with many conditions, including malignancy, infections, autoimmune disorders, pregnancy and drugs. Materials and methods: We reviewed patients with SS-like lesions on the lymphoedema area seen in our department. Clinical manifestations, histopathologic characteristics, treatment and outcome data were recorded and analysed. Results: We report seven women with a history of surgery for breast cancer with axillary lymphadenectomy. Six of them were on tamoxifen. All of them had various lesions consistent with SS localized predominantly on the limb affected by the postmastectomy lymphoedema, and on the ipsilateral chest, trunk and back. One of them presented bullous lesions. Three of the cases underwent spontaneous remission, two resolved with antibiotic therapy, one healed with corticosteroids, and one with corticosteroids plus antibiotic. Conclusions: Erythematous tender plaques on the area of postmastectomy lymphoedema could be considered an unusual manifestation of Sweet’s syndrome. We have found only three similar cases in the literature. Although it is difficult to elucidate the pathogenesis of this entity, it has been suggested that it could be due to immune surveillance impairment.