Advances in the Correlation between Intestinal Microbiota and Breast Cancer Development
Advances in the Correlation between Intestinal Microbiota and Breast Cancer Development作者机构：Hainan Hospital Affiliated to The Hainan Medical College Central Laboratory Hainan General Hospital Hainan Provincial Key Labor-atory of Cell and Molecular Genetic Translational Medicine Hainan China
出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)
年 卷 期：2020年第11卷第12期
页 面：758-771页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Breast Cancer Microbial Dysbiosis Estrogen Metabolism Immune Response Microbial Metabolism
摘 要：The intestinal microbiota has a symbiotic relationship with humans. It participates in some important physiological activities in the human body and has an important impact on human health. It has become a hot topic of research by scientists in recent years. Among them, the research on the correlation between intestinal microbiota and cancer has increased rapidly. At present, the incidence rate of breast cancer is increasing, which seriously endangers the health of women. More and more studies have found that the occurrence of breast cancer is related to intestinal microbiota, and its possible mechanism includes intestinal microbiota dysbiosis, estrogen metabolism changes, immune regulation, and the participation of intestinal microbiota metabolites, etc. With the further development of high-throughput sequencing technology, the research on the correlation between intestinal microbiota and breast cancer has become more in-depth, from a structural level confined to microorganisms to a more comprehensive system structure and function level. These research results provide a new research direction for the treatment of breast cancer. In order to further study the interaction between intestinal microbes and breast cancer, this article will comprehensively describe the intestinal microbiota and breast cancer from four aspects: intestinal microbial dysbiosis, altered estrogen metabolism, immune regulation, and intestinal microbial metabolites. It also reviews the application research of intestinal microbiota in breast cancer treatment, including the influence of intestinal microbiota on the effects of breast cancer radiotherapy and chemotherapy, probiotic therapy, and dietotherapy.
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