Natural products remodel cancer-associated fibroblasts in desmoplastic tumors

作     者：Rujing Chen Leaf Huang Kaili Hu Rujing Chen;Leaf Huang;Kaili Hu

作者机构：Murad Research Center for Modernized Chinese MedicineInstitute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China Division of Pharmacoengineering and Molecular PharmaceuticsCenter for Nanotechnology in Drug DeliveryEshelman School of PharmacyUniversity of North Carolina at Chapel HillChapel HillNC 27599USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第11期

页      面：2140-2155页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Institutes of Health(Grant No.CA198999,USA) the State Key Laboratory of Molecular Engineering of Polymers,Fudan University(China) the National Natural Science Foundation of China(Grant Nos.81202924 and81773909) Shanghai Rising-Star Program of China(Grant No.13QA1403400) Shanghai talent development funds(Grant No.201665,China) Shanghai municipal commission of health and family planning(Grant No.2017YQ060,China) 

主　　题：Natural products Desmoplastic tumors Cancer-associated fibroblasts Tumor microenvironment Extracellular matrix Traditional Chinese medicine Cancer treatment 

摘      要：Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic *** treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the ***,through modulating cancer-associated fibroblasts(CAFs)which are the most abundant cell type among all stromal cells,natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells,showing promising ability to improve treatment effects on desmoplastic *** this review,we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products,highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment.