Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples
作者机构：Department of Hepatobiliary SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210093China Drum Tower Research Institute of Clinical MedicineNanjing UniversityNanjing 210093China Department of Infectious DiseaseNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210093China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第1期
页 面：5-7页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by grants from the National Key Research and Development Program of China(2016YFC0905900 to B.S.) State Key Program of the National Natural Science Foundation(81930086 to B.S.) The Key Project by Medical Science and Technology Development Foundation,Nanjing Department of Health(ZKX2020001 to S.J.) Fundamental Research Funds for the Central Universities(0214-14380461 to B.S.)
主 题：immunity infection cytotoxic
摘 要：Dear Editor,The SARS-CoV-2 virus outbreak that started in December 2019 is now a global pandemic with over 42.7 million confirmed cases and 1.15 million deaths as of October 25,*** has been predicted that resurgence in contagion may be possible as late as 2024.1 A persistent anti-SARS-CoV-2 adaptive immune surveillance post infection is critical to lower the risk of resurgence and transmission.T cells are the primary effectors of cellular adaptive immunity that not only clear virus-infected cells during infection but also provide long-term protection post infection as memory cells in some pathogen ***,little is known regarding the longitudinal T cell response during and after SARSCoV-2 ***-cell T cell receptor(TCR)sequencing allows rapid identification of expanded T cell clones that are potentially the antigen-specific clonotypes.
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