Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo
作者机构：Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandSt.LuciaQLD4072Australia School of DentistryThe University of QueenslandHerstonQLD4006Australia School of ChemistryPhysics and Mechanical EngineeringScience and Engineering FacultyQueensland University of Technology(QUT)BrisbaneQLD4001Australia
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2021年第14卷第3期
页 面：770-777页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 08[工学] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学]
基 金：the support from University of Queensland (UQ) Early Career Researcher Grant (No.1717673)
主 题：tissue engineering scaffolds hydroxyapatite dendritic mesoporous silica nanoparticles
摘 要：Biomaterial based scaffolds for treating large bone defects require excellent biocompatibility and *** we report on the fabrication of hydroxyapatite-dendritic mesoporous silica nanoparticles(HA-DMSN)based scaffolds with hierarchical micro-pores(5µm)and nano-pores(6.4 nm),and their application for bone *** in vitro studies demonstrated good biocompatibility of dissolution extracts,as well as enhanced osteogenic potential indicated by dose-dependent upregulation of bone marker gene expression(osteocalcin gene(OCN),osteopontin gene(OPN),collagen type I alpha 1 gene(CoL1A1),runt-related transcription factor 2 gene(RUNX2),and integrin-binding sialoprotein gene(IBSP)),alkaline phosphatise(ALP)activity,and alizarin red *** in vivo studies showed that HA-DMSN scaffolds significantly increased bone formation in a rat cranial bone defect model after 4 weeks *** study provides a simple method to fabricate promising inorganic scaffolds with hierarchical pores for bone tissue engineering.
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