Evaluation of Sub Clinical Myocardial Systolic Dysfunction Using 2D Global Longitudinal Strain Assessment in Type 2 Diabetes Patients in Sub-Saharan Africa

作     者：Alain Patrick Menanga Chris Nadège Nganou-Gnindjio Ladé Viché André Jules Ahinaga Franck Ngowa Guy Sadeu Wafeu Donald Paulin Tchapmi Njeunje Hamadou Bâ Samuel Kingue Alain Patrick Menanga;Chris Nadège Nganou-Gnindjio;Ladé Viché;André Jules Ahinaga;Franck Ngowa;Guy Sadeu Wafeu;Donald Paulin Tchapmi Njeunje;Hamadou Bâ;Samuel Kingue

作者机构：Internal Medicine and Specialities Department Faculty of Medicine and Biomedical Sciences University of Yaoundé Yaoundé Cameroon Internal Medicine Department Yaoundé General Hospital Yaoundé Cameroon Cardiology Department Yaoundé Central Hospital Yaoundé Cameroon Internal Medicine Department Douala General Hospital Douala Cameroon Efoulan District Hospital Yaoundé Cameroon 

出 版 物：《World Journal of Cardiovascular Diseases》 (心血管病（英文）)

年 卷 期：2020年第10卷第10期

页      面：707-715页

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学] 

主　　题：2D Echocardiography Myocardial Strain Left Ventricle Function Diabetes Mellitus Cameroon 

摘      要：Background: Heart failure is the commonest cardiovascular complication in type 2 diabetes mellitus. However, subclinical left ventricular dysfunction can’t be detected using 2D echocardiography which is routinely used for cardiac evaluation of diabetic patients. We aimed to determine the prevalence and factors associated to left ventricular global longitudinal strain (LV GLS) impairment in type 2 diabetes Cameroonians patients. Methods: We conducted a cross-sectional study from January 2019 to June 2019, including type 2 diabetes patients with preserved left ventricle ejection fraction. Clinical and echocardiographic data were collected, and LV GLS was assessed using speckle tracking technique, a value ≤ -16% been considered as normal value. Results: We recruited 95 patients, with a mean age of 57.4 ± 11.8 years old and median diabetes duration of 5 [2 - 12] years. Echocardiographic evaluation found 56.3% of left ventricle remodelling, 51.6% of left ventricle diastolic dysfunction and mean left ventricle ejection of 63.3% ± 6.6%. LV GLS impairment was present in 43.2% (95% CI: 32.6 - 53.7) of the participants. After adjustment to all significantly associated factors, Obesity (aOR: 4;95% CI: 1.5 - 10.6) and diastolic dysfunction (aOR: 3.1;95% CI: 1.2 - 8.2) were independent factors associated with LV GLS. Conclusions: Subclinical systolic dysfunction assessed by LV GLS impairment is frequent in diabetic patients. Further research should be carried out more extensively to integrate LV GLS in the type 2 diabetes patients’ routine follow up for a better prognostic outcome, especially in low-incomes countries.