Idiopathic multicentric Castleman disease with pulmonary and cutaneous lesions treated with tocilizumab:A case report
作者机构：Department of Rheumatology and ImmunologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Rheumatology and Immunologythe Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2020年第8卷第20期
页 面：4922-4929页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：National Natural Science Foundation of China,No.81801600 Shanghai Sailing Program,No.18YF1414500
主 题：Multicentric Castleman disease Lymphocytic interstitial pneumonia Skin involvement Interleukin 6 Tocilizumab Case report
摘 要：BACKGROUND Human herpes virus-8(HHV-8)-negative,idiopathic multicentric Castleman disease(iMCD)is a rare and life-threatening disorder driven by proinflammatory cytokines,which is still poorly *** parenchyma lesion is a rare condition in iMCD,which mainly manifests as lymphocytic interstitial pneumonia and is an indicator of severe *** lesion is also very rare and mainly occurs in *** have been few reports of iMCD patients with both skin and lung parenchyma *** SUMMARY We present a Chinese man who complained about a 3-year history of intermittent dry cough and a 2-year history of diffuse reddish-brown *** examination revealed polyclonal hypergammaglobulinemia and hypercytokinemia including interleukin *** computed tomography revealed small patchy shadows with ground-glass nodules scattered in two lobes and mediastinal *** pathological result of the lymph node was consistent with the plasma cell type of Castleman *** serum human immunodeficiency virus test and HHV-8 staining of the lymph node were negative,the patient was finally diagnosed with HHV-8 negative i *** was treated with tocilizumab at an intravenous(i.v.)dose of 8 mg/kg every 2 wk combined with methylprednisolone at an *** of 80 mg/d initially with gradual dose *** remission was achieved 9 mo *** i MCD with lung parenchyma and skin involvement is a rare condition that requires clinicians attention and awareness for early diagnosis.
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