Dehydrated patient without clinically evident cause:A case report

作     者：Federica Palladino Maria Cristina Fedele Marianna Casertano Laura Liguori Tiziana Esposito Stefano Guarino Emanuele Miraglia del Giudice Pierluigi Marzuillo 

作者机构：Department of WomanChild and of General and Specialized SurgeryUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第20期

页      面：4838-4843页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Metabolic alkalosis Dehydration Cystic fibrosis Pseudo-Bartter syndrome Heat exposure Children Case report 

摘      要：BACKGROUND Patients affected by cystic fibrosis can present with metabolic alkalosis such as Bartter s *** this case report we want to underline this differential diagnosis and we aimed focusing on the suspect of cystic fibrosis,also in case of a negative newborn *** SUMMARY In a hot August–with a mean environmental temperature of 36℃–an 8-mo-old female patient presented with severe dehydration complicated by hypokalemic metabolic alkalosis,in absence of fever,diarrhea and *** diagnosis between cystic fibrosis and tubulopathies causing metabolic alkalosis(Bartter s Syndrome)was *** started intravenous rehydration with subsequent improvement of clinical conditions and serum electrolytes *** diagnosed a mild form of cystic fibrosis(heterozygous mutations:G126 D and F508 del in the cystic fibrosis transmembrane conductance regulator gene).The trigger factor of this condition had been heat *** When facing a patient with hypokalemic metabolic alkalosis,cystic fibrosis presenting with Pseudo-Bartter s syndrome should be considered in the differential diagnosis,even if the newborn screening was negative.