Associations of content and gene polymorphism of macrophage inhibitory factor-1 and chronic hepatitis C virus infection
作者机构：Department of Laboratory MedicineThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of PathologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325006Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第41期
页 面：6378-6390页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Supported by the Medical and Health Research Science and Technology Plan Project of Zhejiang Province No. 2016KYB191
主 题：Hepatitis C virus Chronic infection Exon region Polymorphism Macrophage inhibitory factor-1 Case-control study
摘 要：BACKGROUND The expression of macrophage inhibitory factor-1(MIC-1) is increased in peripheral blood of patients with chronic hepatitis and liver cirrhosis. However, whether MIC-1 gene polymorphism is correlated with relevant diseases is not yet *** To explore the correlation between gene polymorphism in MIC-1 exon region and chronic hepatitis C virus(HCV) *** This case-control study enrolled 178 patients with chronic hepatitis C(CHC) in the case group, and 82 healthy subjects from the same region who had passed the screening examination comprised the control group. The genotypes of rs1059369 and rs1059519 loci in the MIC-1 gene exon were detected by DNA sequencing. Also, the MIC-1 level, liver function metrics, liver fibrosis metrics, and HCV RNA load were determined. Univariate analysis was used to compare the differences and correlations between the two groups with respect to these parameters. Multivariate logistic regression was used to analyze the independent relevant factors of *** The plasma MIC-1 level in the CHC group was higher than that in the control group(P 0.05), and it was significantly positively correlated with alanine aminotransferase, aspartate aminotransferase(AST), type III procollagen N-terminal peptide(known as PIIINP), type IV collagen, and HCV RNA(P 0.05), whereas negatively correlated with total protein and albumin(P 0.05). The genotype and allele frequency distribution at the rs1059519 locus differed between the two groups(P 0.05). The allele frequency maintained significant difference after Bonferroni correction(Pc 0.05). Logistic multiple regression showed that AST, PIIINP, MIC-1, and genotype GG at the rs1059519 locus were independent relevant factors of CHC(P 0.05). Linkage disequilibrium(LD) was found between rs1059369 and rs1059519 loci, and significant difference was detected in the distribution of haplotype A-C between the CHC and control groups(P 0.05). Meanwhile, we found the MIC-1 leve
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