Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats

作     者：Jiazhi Chen Qiang Wang Nanxiang Li Shujie Huang Min Li Junbin Cai Yuzheng Wang Huantao Wen Siyuan Lv Ning Wang Jinyan Wang Fei Luo Wangming Zhang Jiazhi Chen;Qiang Wang;Nanxiang Li;Shujie Huang;Min Li;Junbin Cai;Yuzheng Wang;Huantao Wen;Siyuan Lv;Ning Wang;Jinyan Wang;Fei Luo;Wangming Zhang

作者机构：The National Key Clinic SpecialtyThe Engineering Technology Research Center of the Ministry of Education of ChinaGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationDepartment of NeurosurgeryZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Movement Disorders and Neuromodulation UnitDepartment for NeurologyCharite´-University Medicine Berlin10117 BerlinGermany 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第3期

页      面：323-338页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81771210) the Natural Science Foundation of Guangdong Province,China(2015A030313288) 

主　　题：Parkinson's disease Dyskinesia Substantia nigra pars reticulata Primary motor cortex Synchronization 

摘      要：Excessive theta(θ)frequency oscillation and synchronization in the basal ganglia(BG)has been reported in elderly parkinsonian patients and animal models of levodopa(L-dopa)-induced dyskinesia(LID),particularly theθoscillation recorded during periods when L-dopa is withdrawn(the off L-dopa state).To gain insight into processes underlying this activity,we explored the relationship between primary motor cortex(M1)oscillatory activity and BG output in *** recorded local field potentials in the substantia nigra pars reticulata(SNr)and M1 of awake,inattentive resting rats before and after L-dopa priming in Sham control,Parkinson disease model,and LID model *** found that chronic L-dopa increasedθsynchronization and information flow between the SNr and M1 in off L-dopa state LID rats,with a SNr-to-M1 flow *** with the on state,θoscillational activity(θsynchronization and informationflow)during the off state were more closely associated with abnormal involuntary *** findings indicate thatθoscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1θoscillation may participate in the induction of dyskinesia.