Nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions with carboxylic acid derivatives

作     者：Pengbo Ye Xuan Liu Gang Wang Lei Liu 

作者机构：School of Chemistry and Chemical EngineeringShandong UniversityJi'nan 250100China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第3期

页      面：1237-1240页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financial supported by the Natural Science Foundation of China(Nos.21722204,21971148) Fok Ying Tung Education Foundation(No.151035) 

主　　题：Oxocarbenium ion Acyclic Nickel Asymmetric catalysis Alkylation 

摘      要：A nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepareβ-alkoxyl carbonyl moieties with diverseα-substituents has been *** method exhibited broad scope of acetals and carboxylic acid derivatives with excellent enantioselectivity and good functional group compatibility,and can be conducted in a gram-scale without obvious loss of efficiency.