Estimation of Postmortem Interval Using Attenuated Total Reflectance:Fourier Transform Infrared Spectroscopy in Adipose Tissues

作     者：Haohui Zhang Qi Wang Kai Zhang Ruina Liu Shuanliang Fan Zhenyuan Wang 

作者机构：Department of Forensic PathologyXi’an Jiaotong University School of MedicineXi’anChina Department of Forensic MedicineChongqing Medical UniversityChongqingChina 

出 版 物：《Journal of Forensic Science and Medicine》 (法庭科学与法医学杂志（英文）)

年 卷 期：2019年第5卷第1期

页      面：7-12页

学科分类：0202[经济学-应用经济学] 02[经济学] 

基　　金：This study was funded by the Council of the National Natural Science Foundation of China(No.81730056) 

主　　题：Adipose tissue attenuated total reflectance-Fourier transform infrared chemometrics postmortem interval 

摘      要：Estimation of postmortem interval(PMI)is vitally important in forensic *** many studies have examined the chemical changes of various tissues over time,no reports using spectroscopic methods in adipose tissue are *** this study,attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy was utilized to collect comprehensive biochemical information from human adipose tissues in vitro at different ***,mice were used as samples for in vivo experiments for more detailed studies on ***,partial least squares(PLS)model for PMI estimation was established based on the acquired spectral dataset of mouse *** spectral variable associated with C=O arising from lipids and free fatty acids was most susceptible to ***,the PLS model appeared to achieve a satisfactory prediction with a root mean square error of cross‑validation of 1.78 days,and the reliability of the model was determined in an external validation set with a root mean square error of prediction of 1.87 *** study shows the possibility of application of ATR-FTIR methods in PMI estimation using adipose tissue.