Antihyperglycaemic activity of ethylacetate extract of Chlorophytum alismifolium in type 2 diabetes:The involvement of peroxisome proliferator-activated receptor-γand dipeptidyl peptidase-4

作     者：Abdulhakim Abubakar Abdullahi Balarabe Nazifi Idris Mohammed Maje Yusuf Tanko Joseph Akpojo Anuka Ezzeldin Mukthar Abdurahman Abdulhakim Abubakar;Abdullahi Balarabe Nazifi;Idris Mohammed Maje;Yusuf Tanko;Joseph Akpojo Anuka;Ezzeldin Mukthar Abdurahman

作者机构：Department of Pharmacology and TherapeuticsAhmadu Bello UniversityZaria PMB-1044Nigeria Department of Pharmacology and TherapeuticsBayero UniversityKano PMB-3011Nigeria Department of Human PhysiologyAhmadu Bello UniversityZaria PMB-1044Nigeria Department of Pharmacognosy and Drug DevelopmentAhmadu Bello UniversityZaria PMB-1044Nigeria 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2021年第19卷第1期

页      面：78-84页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Department of Human Anatomy Ahmadu Bello University, ABU 

主　　题：Chlorophytum alismifolium Diabetes mellitus Gas chromatography-mass spectrometry Insulin Peroxisome proliferator-activated receptor-c Dipeptidyl-peptidase 4 

摘      要：Objective:This research is to investigate the antihyperglycaemic activity and the underlying mechanisms of action of the ethylacetate extract of Chlorophytum alismifolium(EACA)tubers in a type 2 diabetes ***:The tubers were processed and sequentially extracted in hexane followed by ethylacetate,using a Soxhlet apparatus,and subjected to gas chromatography-mass spectrometry(GC–MS).The acute toxicity of EACA was investigated in albino Wistar *** antihyperglycaemic study was carried out using high-fat diet(pelletized diet and margarine in the ratio of 10:1 and 20%fructose solution)and streptozotocin-induced hyperglycaemic Wistar *** effects of the extract(150,300 and 600 mg/kg)on blood glucose level,insulin,peroxisome proliferator-activated receptor-c(PPAR-c)and dipeptidyl peptidase-4(DPP-4)were evaluated using enzyme-linked immunosorbent ***:The oral median lethal dose in Wistar rats was estimated to be5000 mg/*** with EACA at all doses significantly reduced the fasting blood glucose levels,compared to the hyperglycaemic control,and over *** of EACA increased the serum insulin and PPAR-c levels while decreasing DPP-4 ***–MS analysis revealed the presence of 13 compounds,with isothiazole and isoxazolidine covering total area of 24.6%and 22.69%,***:The findings from this study showed that EACA has important compounds with beneficial effect in type 2 diabetes and acts by increasing insulin secretion and PPAR-c level and decreasing DPP-4 activity.