Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K

作     者：Pengbao Lian Qiang Liu Lizhen Chen Cai Cao Jiaxiang Zhao Jianlong Wang Pengbao Lian;Qiang Liu;Lizhen Chen;Cai Cao;Jiaxiang Zhao;Jianlong Wang

作者机构：School of Chemical Engineering and TechnologyNorth University of ChinaTaiyuan 030051China Hubei Dongfang Chemical Industry Co.LtdXiangyang 441403China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2020年第28卷第10期

页      面：2634-2639页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学] 070304[理学-物理化学(含∶化学物理)] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Military Chemistry and Pyrotechnics National Defense Specialty Fund for North University of China 

主　　题：4-Nitroimidazole Laser monitoring system Solid–liquid equilibrium Solubility model Thermodynamic properties 

摘      要：In this paper,the solubility of 4-nitroimidazole in twelve pure solvents(toluene,benzene,1,4-dioxane,acetonitrile,ethyl acetate,acetone,GBL,ethanol,methanol,n-butanol,DMF and NMP)were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 k Pa,which are 0.00018–0.00070,0.00021–0.00073,0.00034–0.00092,0.00038–0.00142,0.00047–0.00120,0.00126–0.00303,0.00225–0.00517,0.00310–0.00724,0.00467–0.00982,0.00453–0.01940,0.01947–0.04652,and 0.04670–0.07452,*** constant temperature,the mole fraction solubility of 4-nitroimidazole were increased as the following order:toluenebenzene1,4-dioxane(ethyl acetate or acetonitrile)acetoneGBLethanol(methanol or nbutanol)DMFNMP,and the solubility of 4-nitroimidazole in(ethyl acetate,acetonitrile)and(methanol,n-butanol)had an intersection point at 297.55 K and 281.85 K,*** solubility of 4-nitroimidazole could be increased with increasing temperature in twelve pure *** ideal model,modified Apelblat equation,polynomial empirical equation,andλh equation were used to correlate the experimental *** experimental solubility values were employed to calculate the standard dissolution enthalpy,standard dissolution entropy and Gibbs *** dissolution of 4-nitroimidazole could be an endothermic process in twelve pure *** determination and fitting solubility of 4-nitroimidazole have important guiding significance for the purification and crystallization of its preparation process.