Microbial transformation of isoangustone A by Mucor hiemalis CGMCC 3.14114

作     者：冯金 梁文飞 季帅 乔雪 张英涛 余四旺 叶敏 Jin Feng;Wenfei Liang;Shuai Ji;Xue Qiao;Yingtao Zhang;Siwang Yu;Min Ye

作者机构：北京大学医学部药学院天然药物及仿生药物国家重点实验室北京100191 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2015年第24卷第5期

页      面：285-291页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Natural Science Foundation of China(Grant No.81173644 and 81222054) the Program for New Century Excellent Talents in University from Chinese Ministry of Education(Grant No.NCET-11-0019) 

主　　题：Isoangustone A Microbial transformation Mucor hiemalis CGMCC 3.14114 Structural diversity Glycosylation Sulfation 

摘      要：Isoangustone A （1） is an isoprenylated flavonoid isolated from licorice. It has been reported to possess anti-microbial, anti-oxidative, anti-inflammatory, and anti-tumor activities. In order to increase its structural diversity, microbial transformation of 1 was conducted by Mucor hiemalis CGMCC 3.14114 to obtain three new compounds. By extensive NMR and MS spectroscopic analyses, their structures were identified as isoangustone A 7-O-glucoside （2）, isoangustone A 7-O-glucoside-4＇-O-sulfate （3）, and isoangustone A 7,3 ＇di-O-glucoside （4）, respectively. The major biotransformation reaction was glycosylation at C-7. Sulfation is rare for microbial transformation.