Roles of miRNAs in spinal cord injury and potential therapeutic interventions

作     者：Badria Almurshidi Wayne Carver Geoff Scott Swapan K.Ray Badria Almurshidi;Wayne Carver;Geoff Scott;Swapan K. Ray

作者机构：Department of Environmental Health SciencesArnold School of Public HealthCENRUniversity of South CarolinaColumbiaSC 29209USA Department of Cell Biology and AnatomySchool of MedicineUniversity of South CarolinaColumbiaSC 29209USA Department of PathologyMicrobiologyand ImmunologySchool of MedicineUniversity of South CarolinaColumbiaSC 29209USA 

出 版 物：《Neuroimmunology and Neuroinflammation》 (神经免疫与神经炎症（英文版）)

年 卷 期：2019年第6卷第10期

页      面：1-11页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The work was supported in part by an investigator-initiated research grant(SCIRF-2015-1-01)from South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA) an award from the Soy Health Research Program(SHRP,United Soybean Board,Chesterfield,MO,USA) and earlier R01 grants(CA-091460 and NS-057811)from the National Institutes of Health(Bethesda,MD,USA) 

主　　题：Spinal cord injury miRNAs astrogliosis neuropathic pain inflammation apoptosis functional recovery 

摘      要：Spinal cord injury(SCI)affects approximately 200,000 individuals per year *** are more than 27 million people worldwide living with long-term disability due to ***,it was thought that the central nervous system(CNS)had little ability for regeneration;however,more recent studies have demonstrated potential for repair within the *** of this,there exists a renewed interest in the discovery of novel approaches to promote regeneration in the CNS including the spinal *** is important to know the roles of the microRNAs(miRNAs)in modulation of pathogenesis in SCI and the potentials of the miRNA-based clinical interventions for controlling post-injury symptoms and improving functional *** miRNAs,which are non-coding RNAs with an average of 22 nucleotides in length,are post-transcriptional gene regulators that cause degradation of the target mRNAs and thus negatively control their *** review article focuses on current research related to miRNAs and their roles in modulating SCI symptoms,asserting that miRNAs contribute to critical post-SCI molecular processes including neuroplasticity,functional recovery,astrogliosis,neuropathic pain,inflammation,and *** particular,miR-96 provides a promising therapeutic opportunity to improve the outcomes of clinical interventions,including the way SCI injuries are evaluated and treated.